[5] Other oral medications used to treat discoid lupus include retinoids (isotretinoin or acitretin), dapsone, thalidomide (teratogenic, side effects include peripheral neuropathy), azathioprine, methotrexate, or gold. Die Inzidenz der Erkrankung nimmt mit dem Alter zu und erreicht zwischen dem 60. und 69. However, it can also present as a diffuse morbilliform eruption with erythema and edem… [5] In addition, pathologists often see groups of white blood cells, particularly T helper cells, around the follicles and blood vessels in the dermis. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosusspectrum of illnesses. Pronunciation of discoid lupus erythematosus with 1 audio pronunciation, 4 synonyms, 2 meanings, 10 translations and more for discoid lupus erythematosus. The center areas may appear lighter in color with a rim darker than the normal skin. Discoid lupus on the other hand, usually causes a much more pronounced, and sometimes scarring, rash on the face and may also result in severe hair loss and scarring of the scalp. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Liegt der Herd im Bereich der behaarten Kopfhaut, entwickelt sich darüber hinaus eine bleibende Alopezie. Bei Afrikanern kommt die Erkrankung häufiger vor. [12], Dogs and horses can also get discoid lupus. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. Die Erkrankung äußert sich durch rötliche, scheibenförmige Hautareale, die häufig, aber nicht immer, mit festhaftenden Schuppen und Krusten belegt sind. [3] Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. Clin Exp Dermatol. Women are affected by discoid lupus more than men, and it appears to run in families so there is a genetic factor involved. Description The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus (SLE). Beim kutanen Lupus erythematodes (lat. Hair loss may occur if the lesions are on the scalp. [3] The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. [3] These lesions can last for years without treatment. [5] Evidence does not clearly demonstrate a genetic component to DLE; however, genetics may predispose certain people to disease. Bitte logge Dich ein, um diesen Artikel zu bearbeiten. [3][5] The epidermis appears thin and has effaced rete ridges as well as excess amounts of keratin clogging the openings of the follicles. In non-responders or after secondary resistance or contraindications, there are a number of alternative therapeutics which are less effective and more toxic. Frauen sollen nach manchen Quellen etwa 3x häufiger betroffen sein als Männer, nach anderen Quellen etwa gleich häufig. [3] More rarely, the lesions may be bright red and look like hives. PubMed Google Scholar 8. [3] They can have a smooth surface or have visible, dilated hair follicles on the surface. In den USA wurde die Prävalenz mit 178/100.000 Personenjahre und die Inzidenz mit 7,5 pro 100.000 Personenjahre bestimmt. Discoid lupus erythematosus most commonly afflicts young adult females, especially individuals of African and Hispanic descent, though it may occur at any age and it occurs worldwide. [5], Possibly, UV light damages skin cells, which then release material from their nuclei. dermis.net:80. dermis.net:80. [4], Finally, many patients with systemic lupus also develop discoid lupus lesions. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.The most common and most severe form is systemic lupus erythematosus J Am Acad Dermatol. 1975 Nov. 111(11):1448-52. . Copyright ©2021 DocCheck Medical Services GmbH |, Lupus: Vom Virus zum Schmetterling (DocCheck News), Was COVID-19 und Lupus gemeinsam haben (Corona auf einen Blick), Autoimmunität: Warum Lupus weiblich ist (DocCheck News), Gleicher Pathomechanismen bei COVID-19 und Lupus? Wenn der Hautauschlag abheilt, können sich Narben bilden. Discoid lupus erythematosus as part of a larger disease spectrum. Selten kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als Lupus erythematosus verrucosus adressiert wird. Die entzündlichen Veränderungen betreffen in erster Linie die Haut. Cutaneous lupus erythematosus, or CLE, refers to forms of lupus that affect the skin, causing rashes and sores. [3], Some experts consider hypertrophic lupus erythematosus—which consists of lesions covered by a very thick, keratin-filled scale—an unusual subset of discoid lupus. Hyperpigmentierungen und Teleangiektasien kommen ebenfalls vor. Synonyme: chronisch diskoider Lupus erythematodes, CDLE, Lupus erythematodes chronicus discoides Es gibt aber auch Verlaufsformen, bei denen noch andere Organe mitbeteiligt sind. [3], The differential diagnosis includes actinic keratoses, sebborheic dermatitis, lupus vulgaris, sarcoidosis, drug rash, Bowen’s disease, lichen planus, tertiary syphilis, polymorphous light eruption, lymphocytic infiltration, psoriasis, and systemic lupus erythematosus. [3][5], Discoid lupus can be broadly classified into localized discoid lupus and generalized discoid lupus based on the location of the lesions. Beim diskoiden Lupus erythematodes sind die Effloreszenzen bevorzugt an lichtexponierten Hautarealen wie Kopf, Gesicht, Ohren und behaarter Kopfhaut lokalisiert. [4] These patients have firm, nontender nodules with defined borders underneath their discoid lupus lesions. [5] However, 25% of patients with SLE get discoid lupus lesions at some point as part of their disease. Lupus sometimes runs in families. The face (bridge of the nose, cheeks, lower lip, the ears, or inside the mouth) and/or the scalp are most often affected. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. Discoid lupus erythematosus. These lesion… Lupus erythematodes. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellrest… Seine jährliche Inzidenz liegt bei etwa 5-10 Fällen pro 100.000 Einwohner. We therefore conducted an open study in patients with discoid lupus erythematosus treated with sulfasalazine. Die Prognose des diskoiden Lupus erythematodes ist - mit Ausnahme der Beeinträchtigung der Hautästhetik - insgesamt gut. [3] Patients who develop discoid lupus in childhood also have their own sub-type of disease. [3][5] The basal layer of the epidermis sometimes appears to have holes in it since some of the cells in this layer have broken apart. [2][7] If this does not help the patient, his or her physician can prescribe an antimalarial medication such as oral hydroxychloroquine or chloroquine. Tags: [3] They may also have overlying dried fluid, known as crust. [5] If a patient does not have any signs of systemic lupus erythematosus, such as generalized hair loss, ulcers in the mouth or nose, Raynaud's phenomenon, arthritis, or fever at the time that they develop discoid lupus, they will most likely only have discoid lupus and will never develop systemic lupus erythematosus. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. These lesions develop as a red, inflamed patch with a scaling and crusty appearance. Lupus is a systemic autoimmune disease that occurs when your body's immune system attacks your own tissues and organs. [5], Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. Der diskoide Lupus erythematodes, kurz DLE, ist ein Subtyp des kutanen Lupus erythematodes (CLE). cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. [4] Others consider it a distinct entity. reibender Hemdkragen) können Erkrankungsherde hervorrufen, was man als Köbner-Phänomen bezeichnet. [3] If the patients does indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. [5], Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. Lupus erythematodes verläuft in der Regel schubförmig. Diese Seite wurde zuletzt am 14. Arch Dermatol. Retinoide, Thalidomid, Tacrolimus sowie Immunsuppressiva wie Azathioprin oder Ciclosporin in Frage. [3], If a patient has discoid lupus lesions on top of lupus panniculitis, they have lupus profundus. This condition causes a … [3][6], Darker-skinned patients are often left with severe scarring and skin color changes even after the lesions get better. Electron microscopic studies of paramyxovirus-like structures. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Doggy Odor. [5] The doctor will order tests to check for anti-nuclear antibodies in the patient's serum, low white blood cell levels, and protein and/or blood in the urine. Variant of discoid lupus erythematosus characterized by purplish-blue, tender, chilblain-like nodules mainly involving the toes and fingers, but also occurring on the heels, calves, knees, nose and ears. Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. [1] 2020 Jan. 45 (1):89 … Correlation of clinical features with laboratory findings in lupus erythematosus. Elman SA, Joyce C, Costenbader KH, Merola JF. DLE usually presents in people aged between 20 and 40 years of age. Der diskoide Lupus erythematodes (DLE) ist eine Autoimmunerkrankung der Haut, die sich in Form von roten, klar abgegrenzten, schuppenden Bereichen zeigt. [3] The lesions often lose skin pigment and become white with areas of increased skin pigment, with or without areas of redness, and have a sunken appearance. Neben Umweltfaktoren (z.B. [4] On darker skin, the lesions often lose skin pigmentation in the center and develop increased, dark skin pigmentation around the rim. Englisch: discoid lupus erythematosus. Aus allen Formen des kutanen Lupus erythematodes (CLE) kann sich ein systemischer Lupus erythematodes (SLE) entwickeln. [3], Rarely, patients may have lesions above and below the neck; these patients have generalized discoid lupus erythematosus. The exact cause of DLE is unknown, but it is described as an autoimmune disease where the discoid lupus symptoms present as a rash and … [8], Pulsed dye laser is also an effective treatment for patients with localized discoid lupus. Discoid Lupus Erythematosus (DLE) in Dogs. Disseminated Intravascular Coagulation (DIC) in Dogs and Cats. von griechisch: δίσκος ("diskos") - Scheibe Dr. James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus. Neben Umweltfaktoren (z.B. [5] Typical biopsy findings include deposits of IgG and IgM antibodies at the dermoepidermal junction on direct immunofluorescence. [5][6] The disease tends to affect young adults, and women are affected more than men in a 2:1 ratio. Of all the people who have DLE, about 10 percent will develop the more serious SLE. These patients rarely present with significant organ involvement and generally have a good prognosis (3,4). [5] However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. [8] For oral treatment, hydroxychloroquine and acitretin are equally effective; however, acitretin was associated with more adverse effects. Although DLE may occur at any age, it most often develops in persons aged 20-40 years. [4], Most people with discoid lupus only have lesions above the neck and therefore have localized discoid lupus erythematosus. Es handelt sich um die häufigste Form des kutanen Lupus erythematodes. Diskospondylitis (Intervertebral Disk Infection) in Dogs and Cats. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. [4], Of note, patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. Sie können kreisförmig, oval oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten. an Zehen und Fingern auftreten. Auf unbefallener Haut ist der Test negativ. [4][5] 50% of patients will eventually get better on their own. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. [2][5] The topical steroid fluocinonide is more effective than hydrocortisone in the treatment of discoid lupus erythematosus. discoid lupus erythematosus causes. Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. [3], The musician Seal has this skin condition. Auf dieser Basis unterscheiden Mediziner im Wesentlichen drei Hauptformen der Erkrankung. Die abgeheilte Läsion des chronisch diskoiden Lupus erythematodes ist eine reizlose, eingesunkene Narbe. [4] However, patients who present initially with discoid lupus infrequently develop systemic lupus. In der Regel … [5] If this does not work, an oral medication—most likely hydroxychloroquine or a related medication—can be tried. Die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. DLE is slightly more common in African Americans than in whites or Asians. Typisch für den CLE ist die hypopigmentierte, narbige Abheilung im Zentrum der Effloreszenzen mit Atrophie der Haut. Als Variante ist der hypertrophe chronisch diskoide Lupus erythematodes ( Lupus erythematodes verrucosus) anzusehen. [3], Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). 2017;77:261–7. [3] These patients also typically do not have any abnormal sensitivity to the sun. Hypertrophic lupus erythematosus (HLE) may be more common as a variant of discoid lupus erythematosus (DLE) than is reported in the literature. Hautkrankheit, References ; Prognosis. It gets its name from the coin-shaped lesions it produces. How to say discoid lupus erythematosus in English? Cutaneous lupus erythematosus (CLE) can be divided into three main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. Um diesen Artikel zu kommentieren, melde Dich bitte an. Discoid lupus erythematosus mainly affects skin that is exposed to sunlight and doesn’t typically affect vital internal organs. Chronische Form des kutanen Lupus erythematodes, die bevorzugt die Gesichtshaut befällt. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. If you have discoid lupus, you may develop chronic inflammatory sores on your face, ears, scalp, and other areas of the body. Im oberen Korium sieht man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern. [3], The lesions are diagnosed by biopsy. [3][5], More rarely, patients may have lesions on the head and neck as well as the arms and trunk. [5] The remains of skin cells that have died through a process called apoptosis are visible in the upper layer of the dermis and the basal layer of the epidermis. Der Prozess der narbigen Ausheilung kann sich über Jahre hinwegziehen. [3][5] This finding is 90% sensitive; however, false positives can occur with biopsies of facial lesions. There are several types of cutaneous lupus. Development of classification criteria for discoid lupus erythematosus: results of a Delphi exercise. Discoid lupus is the most common type of CLE. [3][5], In order to help with diagnosis, the doctor may peel off the top layer of scale from a patient's lesions in order to look at its underside. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellreste darstellen. Die Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit (Hypersensitivität) auf. Introduction: Antimalaria agents and thalidomide are two reference drugs for discoid lupus erythematosus. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. Die Herde sind randbetont. Dust Mites: Minimizing Exposure in Dogs and Cats. [10], Discoid lupus erythematosus is a chronic condition, and lesions will last for several years without treatment. Discoid lupus (discoid lupus erythematosus) is a chronic autoimmune disease affecting the skin. Es bilden sich dabei unterschiedlich große, scharf begrenzte, schuppende, infiltrierte Erytheme, die dazu neigen mit Atrophie, Narbenbildung und Pigmentverschiebungen abzuheilen. [3], When patients develop discoid lupus in childhood, it differs from typical discoid lupus in several ways. [1][2] It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. Eine erhöhte Lichtempfindlichkeit ist bei Lupus erythematodes häufig, und so zeigen sich die Hautveränderungen auch meist auf lichtexponierten Stellen, typischerweise als „Schmetterlingserythem“ im Gesicht. Discoid lupus erythematosus, unlike the other varieties of its group, affects only the skin in general and does not lead to any other systemic health issues. Distichiasis Requires Permanent Eyelash Removal in Dogs. [3] Patients with generalized discoid lupus often have abnormal lab tests, such as an elevated ESR or a low white blood cell count. It … Bei einem kleinen Teil der Patienten (< 5%) kann der kutane Lupus in einen systemischen Lupus erythematodes (SLE) übergehen. Schlägt die Standardtherapie nicht an, kommen u.a. [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. The most common types are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid lupus (DLE). [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. [3], Diagnosis is confirmed through biopsy. [5] This material diffuses to the dermoepidermal junction, where it binds to circulating antibodies, thereby leading to a series of inflammatory reactions by the immune system. [3][5] In addition to lesions in the typical above-the-neck locations, patients with generalized discoid lupus often have lesions on the thorax and the arms. Hautreizungen (z.B. Der diskoide Lupus erythematodes kommt weltweit vor. [3] On lighter skin, the lesions often develop a gray color or have very little color change. Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen. Skin lesions of DLE are mainly localized in sun-exposed areas and may lead to scarring and disfigurement. Dezember 2018 um 14:40 Uhr bearbeitet. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Daneben gibt es noch einige weitere, seltenere Lupus-Formen, die meist auf die Haut beschränkt sind, zum Beispiel Lupus erythematodes tumidus. DLE is different from systemic lupus erythematosus (SLE), the most common form of lupus, which can affect any part of the body. [3], When discoid lupus is on the lip, it often has a gray or red color with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a surrounding rim of redness. [5] Patients are first treated with sunscreen and topical steroids. Sehr selten entwickelt sich auf alten Narbenbezirken ein Plattenepithelkarzinom. [13][14], Cutaneous keratosis, ulcer, atrophy, and necrobiosis, Systemic lupus erythematosus with discoid lupus lesions. [3] These patients are often bald, with abnormal skin pigment on their scalp, and have severe scarring of the face and arms. Es können auch andere Körperregionen betroffen sein, wie das Dekolleté oder die Streckseiten der Extremitäten. [3], The skin lesions are most often in sun-exposed areas localized above the neck, with favored sites being the scalp, bridge of the nose, upper cheeks, lower lip, and ear and hands [3][5] 24% of patients also have lesions in the mouth (most often the palate), nose, eye, or vulva, which are all mucosal parts of the body. [3], Hypertrophic lupus and lupus profundus are two special types of discoid lupus distinguished by their characteristic morphological findings. Discoid lupus is an autoimmune disease where the immune system attacks the skin. Systemic lupus, which is so called because it affects internal organs, generally produces a mild rash or flush on the face. Less than 2% of patients with DLE have an onset before 10 years of age. Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. [5], Alternatively, dysfunctional T cells may lead to the disease. [5] In addition, these patients have an increased, though still small, risk for aggressive skin squamous cell carcinoma. The exact reason of discoid lupus erythematosus is still not known, but the suspected cause implicates towards autoimmune disorder, which is usually responsible for forcing the immune system of the body to attack its own healthy … Ist stark abhängig von der ethnischen Zugehörigkeit einen neuen Artikel im DocCheck Flexikon.! 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Sunscreen and topical steroids eine reizlose, eingesunkene Narbe ) discoid lupus erythematosus ) in Dogs and Cats disease the.