Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice. "The earth laughs in flowers." It contains a number of phytochemicals known to exert anticarcinogenic effects, and when its water extract is fortified with several constituents endemic to the plant, namely isovanillin, linolenic acid, and β-sitosterol, a synergistic anticarcinogenic effect is seen against prostate cancer cells. Cole14 examined the toxicity of GZ17 against normal human islet cells and prostate cancer cells and found the dose-dependent toxicity of GZ17 was not mirrored in healthy islet cells, as shown in Figure 7A. While we await further clinical studies to be done, I believe the Afaya Plus should be considered a safe and beneficial supplement for cancer patients looking to improve their chance of having a good outcome with their disease. Changes in body weight in mice treated with GZ17 vs vehicle. Approximately 14 g of Arum palaestinum Boiss leaves and roots were placed in 1 L of water and brought to a boil for 15 min, followed by reduced heat for another 15 min. INTRODUCTION Many plants and medicinal herbal extracts are used in the treatment of various ailments. seed collections: Seed Collections. The data to date i… Tanagornmeatar K, Chaotham C, Sritularak B, et al. is a time-honored botanical in Traditional Arabic Palestinian herbal medicine, where it has been used to strengthen bones and treat cancer, parasites, infections, and many other maladies. Vishwakarma V, New J, Kumar D, et al. … Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. The lipophilic fractions of Arum palaestinum, Malva sylvestris, Plantago major, Centaurea iberica, Cichorium endivia, Bituminaria bituminosa, Sisymbrium irio leaves were sequentially separated with a nonpolar solvent hexane, while the hydrophilic fractions of the studied plants were separated with polar solvents ethanol and water. Among three formulations tested of Arum palaestinum (GZ17-S, a fortified version of the plant extract; GZ17-05.00, 16 components of the original plant extract; and GZ17-06.02, 3 components of the original plant extract), we found formulation GZ17-06.02 to be the most effective at reducing cancer cell proliferation, migration, and invasion. Brilliant red seeds of Arum palaestinum. Arum palaestinum was little known in the United States until recent years. Table 1. Notable Constituents of Arum palaestinum, esculetin-O-hexoside, quercetin dihexoside, 6,8-Di-C-β-glucosylapigenin (Vicenin 2),15 di-C-glucosylluteolin, lucenin-2, vitexin-O-glucoside, quercetin-O-rhamnosylrutinoside, kempferol-O-rutinoside-O-glucoside isomers, isoshaftoside, shaftoside, Di-C-glucosylluteolin, kaempferol trihexoside, cyanidin-3-rutinoside,16 diosmetin-6,8-di-C-hexose, (epi)catechin,17 isoorientin,18 orientin,19 pseudobaptigenin-O-hexoside (rothindin), aromadendrin-O-hexoside, kaempferol, hexoside, luteolin hexoside, isovitexin,20 vitexin,23,19 naringenin-7-neohesperidoside, diosmetin-7-neohesperidoside, chrysoeriol dihexoside, chrysoeriol-7-β-D-glucoside, (+)-eriodictyol,21 luteolin,22,23 hesperitin,24 chrysoriol,25 tricin-7-glucoside, kaempferol-3-O-2″-(6‴-p-coumaroyl) glucosylrhamnoside, feruloylsaponarin, quercetin-3-O-β-D-(6″-O-(E)-p-coumaryl) glucopyranoside, kaempferol-3-O-(6″-O-p-coumaroyl) glucoside (potengriffioside A), caffeoyl-hexose, coumaryl-hexose isomers, caffeoyl-fructofuranosyl-glucopyranoside or 6-O-caffeoylsophorose, feruloylsucrose isomers, ferulic acid hexoside, (trans)caffeoylshikimic acid isomers, rosmarinic acid,26 4-caffeoyl-5-feruloylquinic acid, blumenol-C-9-O-β-(6′-O-rhamnosyl-2′-O-β-glucuronosylglucoside), euphopubescenol,27 Taxchinin J, masilinic acid28 or corosolic acid,29 humilinolide C, Amino acid and Amino acid-sugar derivatives, trihydroxystearic acid, trihydroxy-10-transoctadecenoic acid, trihydroxy-10,15-octadecadienoate I & II, linoleic acid 13-hydroperoxide I & II, linolenic acid monoglyceride, kahweol palmitate,33 α-linolenic acid,34,35 triglochinin isomers, [6]-shogaol,36 gingerglycolipid A, dihydrocapsiate,37 Vitamin B4, 2,6-tert-butylphenol. Next, I would take it with food - its absorption is very poor so taking it with fats will improve its absorption. On this episode we learn more about the fascinating Mediterranean botanical Arum Palaestinum. Herbal medicine (botanical medicine or phytomedicine) is a concept used to describe the usage of plant's roots, seeds, bark, stems, flowers, or leaves for medicinal purposes. By Arum Palaestinum Get YOUR BOTTLE. Early results show that the Afaya Plus blend of herbal extracts has exhibited strong anticancer effects both in vivo and in vitro. Yuan L, Wang J, Xiao H, et al. Wu XX, Kakehi Y. Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by cisplatin in caspase-dependent manner. Narisawa T, Fukaura Y, Yazawa K, et al. Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Yuan L, Wei S, Wang J, et al. Figure 8. Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Mit diesem Duft, so stand zu vermuten, lockt die Schwarze Calla ihre Bestäuber an, nämlich Fruchtfliegen. Among three formulations tested of Arum palaestinum (GZ17-S, a fortified version of the plant extract; GZ17-05.00, 16 components of the original plant extract; and GZ17-06.02, 3 components of the original plant extract), we found formulation GZ17-06.02 to be the most effective at reducing cancer cell proliferation, migration, and invasion. These striking flowers hail from the rugged reaches of the Middle East In comparison, analysis of the ethyl acetate fraction by El-Desouky revealed the presence of the polyhydroxy alkaloid compound (S)-3,4,5-trihydroxy-1H-pyrrol-2(5H)-one, caffeic acid, isoorientin, luteolin, vicenin 11, and the rare compound 3,6,8-trimethoxy, 5,7,3',4'-tetrahydroxy flavone.12 Further work by Afifi13 demonstrates the presence of 2 flavone C-glucosides, specifically isoorientin (luteolin 6-C-glucoside) and also vitexin (apigenin 8-C glucoside). On this episode we learn more about the fascinating Mediterranean botanical Arum Palaestinum. They are native to Europe and the Mediterranean region and although some of them omit an unpleasant smell, to attract insects for pollination, they are well worth growing. Most interestingly, the additives themselves used to fortify the extract show no significantly differing effects compared to the unfortified extract of Arum palaestinum. It is native to the Levant and other parts of the Mediterranean Basin. Arum palaestinum Boiss. Figure 4. The results showed that Arum palaestinum extracts were found to be most effective against leukemia (k562) and colon cancer (HCT-116), and ethyl acetate extracts showed the best effect. Abu-Reidah IM, Ali-Shtayeh MS, Jamous RM, et al. [2,4,5,6, 7]. (commonly known as Italian lords and ladies), and Arum maculatum L (known as cuckoo pint).4 Species of Arum have been in the Mediterranean region for millennia, and are represented in engraved drawings in the temple of Thutmose III in Karnak as plants that were brought to Egypt from Canaan in 1447 BCE.5. It is native to Western Asia, Northern Africa, Europe and widely distributed in Mediterranean region [1]. https://www.naturalmedicinejournal.com/journal/2019-02/arum-palaestinum-food-medicine. Figure 3. If Arum Palaestinum is the engine that drives the Afaya Plus ® formula, then Peganum Harmala is the high-octane gasoline that helps achieve peak performance. Thus, the measurable anticarcinogenic effects of the fortified extract of Arum palaestinum are accompanied by an understood mechanism of action that could apply across multiple types of solid tumors. Einfach auf eine Untertasse oder Schale legen und auf die Fensterbank stellen - in ca. Cooperative Extension, which staffs local offices in all 100 counties and with the Eastern Band of Cherokee Indians. aBoldface text indicates anticancer action for individual constituents or constituents studied in combination with other phytochemicals found in Arum palaestinum. Caspase-6 is a known pro-apoptotic protein whose expression in prostate intraepithelial tissue is significantly increased in precancerous and frankly cancerous tissue compared to normal prostate glandular tissue.43 Additionally, the pro-apoptotic effect of caspase-6 is also associated with the anticancer effects of both natural and drug products in multiple other solid tumor cell lines.44,45. Due to quarantine, cannot post to Overseas. 1 Arum palaestinum has a wide use in traditional medicine. Here we tested the antitumor efficacy of synthetic formulations of Arum palaestinum extract (GZ17-S, -05.00 and -06.02) in preclinical models of HNSCC. Arum is a genus of flowering plants in the family Araceae, native to Europe, northern Africa, and western and central Asia, with the highest species diversity in the Mediterranean region. Arum palaestinum NC State University and N.C. A&T State University work in tandem, along with federal, state and local governments, to form a strategic partnership called N.C. ABOUT HYATT Arum Palaestinum: Then and Now Learn about Arum Palaestinum from Hyatt Life Sciences Vice President of Science & Technology Preston Moore during his interview by MindBody Radio. In fact, Arum palaestinum Boiss is one of the most commonly utilized plants for cancer patients in the region . B, Half maximal inhibitory concentration (IC50) of GZ17 against prostate cancer cells is lower than vascular smooth muscle cells and human fibroblasts. The purple spathe and reddish spadix of Arum palaestinum. Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation. Arum palaestinum makes a glamorous choice for the garden. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. Acute dosing animal studies and in vitro studies, which compare effects on cancerous and healthy cell lines, show toxicity thus far limited to cancer cells. Arum is used for colds, swelling (inflammation) of the throat, congestion, and other conditions, but there is no good scientific evidence to support these uses. >korolkowii and an Arum I was given by a colleague in Puglia, Italy. Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. Checking stock, please wait.. BULBS: BARPA. acid, trihydroxy-10,15-octadecadienoate I & II, linoleic acid 13-hydroperoxide I & II, linolenic acid monoglyceride, www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=811045#null, www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=42543#null, Agaricus bisporus Mushroom in Biochemically Recurrent Prostate Cancer, Botanical Treatment of Bacterial Prostatitis, catalposide isomers, volvaltrate C, (+)-syringaresinol β-D-glucoside. Figure 7. Definitely change fertilizers or at least supplement with a nitrate source. Mice received either the vehicle (purified water) or GZ17 by oral gavage at a dose of 1,000 mg/kg. Liu K, Cho YY, Yao K, et al. In summary, the results suggest that Arum palaestinum has shown anti-tumor activity which were strongly correlated with their bioactive contents. Verified prostate cancer cells were plated as 3D spheroids to determine the effect of extract from boiled Arum Palaestinum Boiss roots. Profaya™ is a scientifically researched combination of natural ingredients intended to augment a healthy lifestyle in canines. Benton Bramwell, ND, graduated from the National University of Naturopathic Medicine in 2002. These wonderful plants have been grown and used for over a millennia in Central and Southeast Asia and the Middle East. Antileukemic activity of phenylalanine methyl ester (PME): a lysosomotropic peptide methyl ester. By day 6 and for all subsequent measurements there was a statistically significant increase in the tumor volume of the vehicle-treated mice. Arum palaestinum, a perennial plant that produces a deep purple lily flower, has a long history of use as a medicinal plant in the Middle East, including as a cancer treatment. Maslinic acid, a natural triterpene, induces a death receptor-mediated apoptotic mechanism in caco-2 p53-deficient colon adenocarcinoma cells. Nearly 40 % of the cancer patients ingesting the plant revealed that they anticipated a cure due to the plant. Moreover, an extract of Arum palaestinum fortified with isovanillin, linolenic acid, and β-sitosterol shows very promising action against prostate cancer cells in vitro and in a mouse model. 5 Wochen bekommt sie … Here's a new video of one of the beautiful plants in my garden. Arum creticum produces a sweet, flower-like odour and is pollinated by bees and bugs. Ku CY, Wang YR, Lin HY, et al. Afaya Plus should be taken with a fat-containing meal and is typically dosed at two capsules, 1-3 times a day. מגדיר צמחי הבר של ארץ ישראל.Study of wild plants of the holy land, Israel He manages a private practice and also provides consulting services to food and dietary supplement industries in matters of scientific and regulatory affairs. According to Yaniv,5 the de-stemmed leaves, cooked with lemon or sorrel, are considered a delicacy by Arabs, who also traditionally esteem the plant as a medicine for the treatment of cancer, for the killing of worms in animals and humans, as a means to strengthen bones, as a treatment for infections in open wounds, and as a treatment for kidney stones. Bhardwaj M, Cho HJ, Paul S, et al. Arum TSN 42543. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. is a time-honored botanical in Traditional Arabic Palestinian herbal medicine, where it has been used to strengthen bones and treat cancer, parasites, infections, and many other maladies. Yang Y, Wolfram J, Boom K, et al. 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